Dominique Smeets

Dominique Smeets 2018Dominique Smeets is clinical laboratory genetisist and head of the team Fertility and Pregnancy

Expertise
Within our team genetic diagnostics is mainly focussed on (in)-fertility and pregnancy. Genetic analysis can be carried out before (prenatal) or after (postnatal) birth.

Prenatal studies, performed on amniotic fluid cells or chorionic villi, are performed in order to detect a potential chromosomal abnormality in the fetus. Indications for amniocenteses or chorionic villi biopsy can be for instance an increased risk for having a fetus with Down syndrome based on a screening test in the mother, family history, or ultrasound anomalies detected in the fetus.

Frequent indications for postnatal genomic studies are sub- or infertility, multiple unexplained spontaneous miscarriages, potential sex chromosomal abnormalities (e.g. Turner syndrome) or unclear gender. Biopsies from intrauterine deceased children are often studied too, in search for the cause of the fetal demise. Finally, the so-called chromosome breakage syndromes like Ataxia Telangiectasia, Fanconi anemia, Bloom syndrome and Nijmegen Breakage syndrome are important focusses within our team.

Studied tissues
Chorionic villi, amniotic fluid cells, blood samples, skin biopsies, buccal cells

Applied techniques
Tissue culturing, routine karyotyping, fluorescence in situ hybridization (FISH), QF-PCR and whole genome SNP array (Affymetrix; applied in both pre- and postnatal diagnostics).

Our team

Our team consists of passionate and experienced people

 

Ms. Helger Yntema, PhD Head Genome Diagnostics, clinical laboratory geneticist
Marcel Nelen, PhD Deputy head Genome Diagnostics, Head team Core Genome Analysis Laboratory, clinical laboratory geneticist
Erik-Jan Kamsteeg, PhD Head team Muscular, Neurological, Renal & Sensory disorders, clinical laboratory geneticist
Dominique Smeets, PhD Head team Fertility & Pregnancy, clinical laboratory geneticist
Ms. Nicole de Leeuw, PhD Head team Intellectual Disability, Multiple Congenital Abnormalities & Endocrine disorders, clinical laboratory geneticist
Ms. Marjolijn Ligtenberg, PhD Head team Laboratory Tumor Genetics, associate professor Tumor Genetics, clinical laboratory geneticist
Lisenka Vissers, PhD Head team Translational Genomics, molecular geneticist
Hans Scheffer, PhD Associate professor clinical molecular genetics, clinical laboratory geneticist
Ms. Brigitte Faas, PhD Clinical laboratory geneticist
Rolph Pfundt, PhD Clinical laboratory geneticist
Ms. Marian Stevens-Kroef, PhD Clinical laboratory geneticist
Ms. Annet Simons, PhD Clinical laboratory geneticist
Arjen Mensenkamp, PhD Clinical laboratory geneticist
Ms. Daniel Olde Weghuis, PhD Clinical cytogeneticist
Ms. Tuula Rinne, PhD Clinical laboratory geneticist
Ms. Dorien Lugtenberg, PhD Clinical laboratory geneticist
Christian Gilissen, PhD Bioinformatician
Ms. Kornelia Neveling, PhD Molecular geneticist